Abstract
Cell culture is an integrated part of many biomedical applications, especially virus or cell detection systems. In such a system, a compact, feasible and precise thermal cycler is highly desired due to the decisive role of temperature in the cell culturing process. This study proposes a novel design of thermal cycler to improve the ease of manipulation and fabrication, while maintaining the required accuracy of temperature handling. Specifically, the propsed system uses a popular semiconductor component called Peltier as heat generation source, which operates efficiently in the range of 15°C to 80°C. A relatively large operation range ensures that the proposed Peltier-based heating device could well fit in most temperature-dependent applications, including cell culturing process. Additionally, the system behavior is controlled by PID algorithm to improve the efficiency of temperature regulation. The system performance is verified in Isothermal Amplification-based cell culture application, which shows competitive result (maximum variation within 1°C) as compared with other thermal cyclers with sophisticated heating technology.
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Disclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.