Development of a sustained-release matrix tablet formulation of DHEA as ternary complex with α-cyclodextrin and glycine

Abstract

Sustained-release matrix-tablets of dehydroepiandrosterone (DHEA) as ternary complex with α-cyclodextrin and glycine (c-DHEA) were prepared by direct compression with suitable excipients. The influence of the swelling properties of hydroxypropylmethylcellulose (HPMC) and the disintegrating power of Explotab® used in combination, as well as the effect of the presence, type and amount of suitable channelling agents (Emcocel® and spray-dried lactose, alone or in combination) on drug release behaviour from matrix-tablets has been evaluated.