Abstract
A standardized analysis strategy for basic drugs which had been applied previously to pharmaceutical dosage forms, cosmetics and saliva has been applied to plasma. Low extraction recoveries that were obtained at first were shown by protein binding studies to be due to interactions between plasma proteins, the drug and the organic ion-pairing reagent. These interactions could be avoided by removal of the plasma proteins from the sample prior to addition of the counterion solution. The standardized analysis strategy was shown to be applicable to the determination of both polar and non-polar drugs in plasma.
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