Abstract
In recent years, the maternal-age associated increase in egg aneuploidy has been documented in several mouse strains, but it is not known whether specific chromosomes are prone to segregation errors. This is in part due to lack of established methodologies for chromosome-specific and comprehensive evaluation of aneuploidy in individual mouse eggs. This study develops the first such strategy to provide a new research tool to improve the basic understanding of the molecular mechanisms contributing to maternal-age associated aneuploidy in mammals.
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