Abstract
Aim: To develop a single scan protocol for the SPET tracer 123I-ADAM, which binds to serotonin transporters in the brain. Method: Dynamic SPET scans were performed on 15 healthy volunteers over a period of ∼5.5 h after i.v. injection of ∼150 MBq 123I-ADAM. Images were reconstructed by filtered back-projection with scatter and attenuation correction. Tracer binding was quantified for midbrain, striatum and thalamus using cerebellum as a reference region. Three different kinetic analysis methods were used: simplified reference tissue modelling (SRTM), graphical analysis (GA) and multi-linear regression (MLR). In addition, quantification was also made by a simple ratio method, with data corresponding to different time intervals after injection. Results: The rank order of 123I-ADAM binding was: midbrain>thalamus>striatum. There was a good agreement and correlation between SRTM and MLR (slope=0.98–1.01, R2=0.94–1.00), and less agreement but still good correlation between SRTM and GA (slope=0.90–0.98, R2=0.94–0.98). With the ratio method, the best results were obtained using data from the period 180–240 min p.i., resulting in the lowest regression intercept and highest correlation (R2=0.76–0.96) as compared to SRTM. Conclusion: Quantitative values of 123I-ADAM binding can be obtained by a 1 h scan carried out 3 h after injection.
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