Abstract
A porous microneedle (MN) patch is expected to be a promising device for extracting the interstitial fluid (ISF) of the human body and detecting various biomarkers from ISF. In a previous study, porous MNs with lactic acid-glycolic acid copolymer (PLGA) was developed as a sensing tool for glucose levels in the ISF. The developed device showed excellent properties of compressive strength and glucose detection ability. However, the previous device used thick filter paper (230 µm thick) as a base-film. Thus, its long ISF migration path could cause the delay of glucose detection. Therefore, in this study, we proposed new microneedle patch without a filter paper, which consists of pelyfe-caprolactune) (PCL)-based MNs on the thin polymer film with a through-hole in the center. The lower melting point of PCL contributes to realize the simple and thin configuration. Thus, it shows excellent sensing capability for glucose detection. In addition, cellulose fiber (C.F.) filler in PCL was effective to improve compression strength of each MN. We expect that our new MN patch with new materials and configuration can be used for a simple and easy-to-use glucose sensor patch for pre-diabetic patients.
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