Development of a shielding device for radiotherapy of breast cancer-bearing mice

Camila R Silva,Saulo Toledo Pereira,Elizabeth Ribeiro Somessari,Celia Marina Napolitano,Martha Simões Ribeiro

doi:10.15392/bjrs.v8i1a.1164

Camila R Silva, Saulo Toledo Pereira + Show 3 more

Open Access

https://doi.org/10.15392/bjrs.v8i1a.1164

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Abstract

Breast cancer is the fifth most common cause of death worldwide. Currently, one of the standard treatments for breast cancer is radiation therapy (RT). On the other hand, mouse models have been used in pre-clinical studies for breast cancer RT, requiring dedicated shielding to exposure the breast region. In this work, we considered the values of the lead attenuation coefficient and the tenth reducing layer for a 60Co irradiator and developed a lead shielding device for breast cancer-bearing mice to be exposed to localized breast RT. Five-kg of lead were exposed to temperature of 340ºC and inserted into an aluminum mold previously adjusted to the dimensions of the device. After solidification, the device was shaped into a cylinder with dimension of 14 x 15 x 7 cm (height x width x thickness, respectively). A round cut-out for breast exposure of 1 cm in diameter was made at 5 cm from the basis of the device. For shielding device validation, we performed calibrations to establish a dose of 10 Gy in the target. Fifteen CaSO4:Dy thermoluminescent dosimeters were distributed along a 50 mL conical tube to simulate the mouse position inside the shielding. The shielding device was placed at a fixed distance of 10 cm from the target for optimal exposure time. After irradiation, the dosimeters were read on a thermoluminescent reader. According to our results, we were able to develop a body-shielding device that assured the required dose for RT of breast cancer in mice.

Highlights

Breast cancer is a noncommunicable disease that constitutes an important public health concern, responsible for the fifth principal cause of cancer death worldwide [1]
radiation therapy (RT) has been used as curative or palliative treatment after breastconserving surgery or postmastectomy to diminish the risk of cancer relapse as well as if cancer has disseminated to other parts of the body [3]
RT can deliver energy in the breast through an external beam or internal radiation

Summary

INTRODUCTION

Breast cancer is a noncommunicable disease that constitutes an important public health concern, responsible for the fifth principal cause of cancer death worldwide [1]. Treatment is based on the type of breast cancer, its stage, and any other patient special condition. It requires multimodality treatment comprising surgery, radiation therapy (or radiotherapy, RT), systemic treatment with chemotherapy, and/or hormone therapy [2]. External beam radiation is the most common type of RT for breast cancer. In this case, the radiation source focuses the radiation on the region affected by the tumor. To advance breast cancer treatment, researches frequently use mice because their small size, lowcost housing and easy handling [4]. In this work we report the development of a lead-based body-shielding device for breast cancer-bearing mice to be exposed to a dose of 10 Gy to the target volume [6]

MATERIALS AND METHODS

RESULTS AND DISCUSSION

CONCLUSIONS