Abstract
bioreactor system with sampling possibilities is introduced for GMP-grade MSC production. The system enables culture from minimal numbers to therapeutic quantities in a controlled environment. The closed design reduces contamination risk and enables operation outside expensive cleanroom facilities. Operator involvement is minimized, limiting labor and production costs. The switch from open, uncontrolled procedures to closed systems for production of cell therapy products presents a major step forward to improved quality, reproducibility and affordability of these therapies.
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