Abstract
The main objective of this study was to evaluate the potential of ropivacaine-loaded nanostructured lipid carriers (RPV-NLCs) as a transdermal delivery system. RPV-NLCs were prepared by the method of emulsion evaporation–solidification at low temperature. The average entrapment efficiency and drug loading of the optimized RPV-NLCs were 81.45 ± 2.16% and 2.95 ± 0.37%, respectively. The average particle size was 203.5 ± 1.2 nm and the zeta potential was −40.2 ± 3.3 mV. The results of in vitro permeation study showed that RPV-NLCs could promote the permeation of RPV through skin to achieve transdermal delivery with Qn of 345.6 ± 12.4 μg cm−2. In the mice writhing test, RPV-NLCs provided analgesic effect by reducing the writhing response with an inhibition rate of 89.1% compared to the control group. In addition, the mechanism of permeation enhancement for NLCs investigated by histopathology study and DSC analysis showed NLCs could interact with stratum corneum, weaken the barrier function and facilitate drug permeation. In conclusion, NLCs could be a promising vehicle for transdermal delivery of RPV.
Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callMore From: Colloids and Surfaces A: Physicochemical and Engineering Aspects
Disclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
