Development of a radioprotective drug based on substances of plant, microbial, zoogenic and inorganic origin

Abstract

Environmental pollution with ecotoxicants makes humanity rethink its attitude to the world around it and accept the concept of the need to protect people and animals living on our planet. This paper presents the results of experimental studies of substances of natural origin for the selection of the most promising ones in order to create a multifunctional means of protecting farm animals in areas of anthropogenic pollution. In vitro experiments on lethally irradiated lymphocytes of the peripheral blood of animals, the radioprotective properties of phytogenic preparations were evaluated, and a three-component radioprotective composition was created. On lethally irradiated laboratory animals, the radioprotective activity of various compositions constructed from microbial biomasses and metabolic products of E. coli “PL-6”, B. bifidum 1 bacterial strains, phyto- and zoo drugs preparations radiomodified at a dose of 4 kGy was tested. From the metabolites of the radiomodified bacterial strain B. bifidum 1 (R6), the phytopreparation “Turmeric” and the biologically active feed additive “Vita-Force M”, the phytozoic microbial preparation FZMP was designed and tested on laboratory animals, which provided protection from radiation death to 80% of lethally irradiated laboratory animals, with 100% death of rats in the irradiation control group.