Abstract
Magnolol (MG) is a small-molecule neolignan polyphenolic compound isolated from the genus Magnolia. The anti-inflammatory, anti-oxidative, anti-diabetic, anti-tumorgenic, anti-neurodegenerative, anti-depressant and anti-microbial properties of MG are well documented in recent literature. These fascinating multiple biological activities of MG encourage research about the development of new delivery and administration approaches able to maximize its potential benefits. This study describes the amino-functionalization of the SBA-15 (Santa Barbara Amorphous) mesoporous matrix by post-synthesis grafting using APTES (3-aminopropyltriethoxysilane) and the characterization of amino-functionalized mesoporous silica SBA-15 loaded with MG in order to achieve modified drug delivery systems. The amino-functionalization of silica SBA-15 was carried out by grafting by refluxing in dry toluene. The powders obtained were characterized texturally by Brunauer-Emmett-Teller (BET) surface area analysis measurements and morphologically by scanning electron microscopy. MG loading degree in the nanoporous matrix was determined by the HPLC method at λ = 290 nm. Results showed that by grafting the amino groups in the silica SBA-15, we obtained amino-functionalized silica SBA-15 with an ordered structure, with specific surfaces and pore sizes that differ from the original matrix, which was reflected in the amount of MG immobilized and release kinetics profile.
Highlights
Magnolia officinalis, a species of Magnoliacea, is one of the most popular traditional Chinese medicines
In a previous work, the authors of the present paper have proposed mesoporous silica matrix, SBA-15 type, for the encapsulation of magnolol [23] and demonstrated that SBA-15 silica is a compatible matrix for magnolol in formulating sustained-release drug delivery systems
Experimental outcomes demonstrated that APTES-modified SBA-15 silica nanoparticles are able to uptake a higher amount of magnolol on their surface
Summary
A species of Magnoliacea, is one of the most popular traditional Chinese medicines. Chinese medicines generally use Magnolia officinalis as a remedy for gastrointestinal disorders, acute pain, anxiety, nervous disturbance, diarrhea, cough, phlegm, and a variety of allergic diseases [1,2,3]. Sci. 2017, 7, 237 anti-microbial [7] properties have been recently demonstrated. This compound regulates hormones, exhibits positive gastrointestinal and uterus modulatory effects, offers cardio-vascular and liver protection and is effective in pain control [8,9,10,11]
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