Development of a prognostic algorithm for risk of retinal vein occlusions under geomagnetic perturbations

Abstract

Aim. To develop a screening and prognostic algorithm for the risk of retinal vein occlusion in geomagnetic disturbances in patients with arterial hypertension.Materials and methods. In total, 1512 patients with arterial hypertension of 1–4 stages were included in the study. Within three years, 391 patients developed retinal venous occlusions. A comparative study of the parameters of systemic and regional hemodynamics, microcirculatory parameters of the eyes of these patients was carried out both in a magnetically calm environment and during geomagnetic disturbances. To simulate the response of microcirculatory bed to stress, a functional pharmacological instillation test was performed with a 10% irifrin solution. To assess the geomagnetic situation, the Кр-index was used, which objectively characterizes fluctuations of the Earth’s magnetic field over a three-hour time interval. The International Classification of Кр values was used.Results. For statistical analysis, 78 studied signs of systemic, regional hemodynamics and microcirculation were selected. The prognostic significance of 30 studied signs was revealed. A training group (1434 people) and an examination group (78 people) were formed. Based on the training group, a predictive algorithm was formed. A number of regularities were established that made it possible to create a system for identifying the risk of retinal vein thrombosis during geomagnetic disturbances in patients with hypertension. To determine the risk of retinal vein occlusion, a coefficient was developed. The sensitivity of algorithm was 89%, the specificity was 94%.Conclusion. A prognostic algorithm for determining the risk of occlusive lesions of the retinal veins during geomagnetic disturbances for patients with arterial hypertension with high sensitivity and specificity (88% и 90%, respectively) was developed.