Development of a pilot-scale HuskyJet binder jet 3D printer for additive manufacturing of pharmaceutical tablets

Abstract

This paper reports a custom-built binder jet 3D printer for pilot-scale manufacturing of pharmaceutical tablets. The printer is equipped with high-throughput piezoelectric inkjet print heads and allows direct control of several key process parameters, including the build layer thickness, amount of jetted liquid binder, and powder spreading rate. The effects of these parameters on the properties of the as-printed tablets were studied using a powder mixture of lactose monohydrate and Kollidon® VA64 (KL) and an aqueous binder containing 5% of KL. The appropriate processing windows for two different powder spreading rates were identified, and the final properties of the printed samples were explained using a dimensionless “degree of overlap” parameter which is defined as the ratio between the penetrating depth of the binder into the powder and the build layer thickness. Lastly, 10% of indomethacin was added to the powder feedstock as a model drug. Drug-loaded tablets were produced at a rate of 32 tablets/min, having an average breaking force of 9.4 kgf, a friability of 2.5%, and an average disintegration time of 8 s. These properties are comparable to commercially available tablets and represent one of the best values reported in the literature of 3D printed tablets thus far.