Abstract
Development of a Novel Suture-less Nerve Coaptation Device
Highlights
Damage to peripheral nerves due to either traumatic injury or oncologic resection can create devastating functional deficits [1]
Current strategies for peripheral nerve repair rely on regeneration or proximal outgrowth aided by microsutures, nerve grafts, or manufactured conduits [2,3]
We set out to develop a novel device/ system using suture-less coaptation for simple and effective nerve repair after injury including segmental nerve defects, in which any surgeon despite their specialty can promptly perform peripheral nerve repairs with positive outcomes and saving precious operative room time for other concomitant injuries that need more attention [7]
Summary
Damage to peripheral nerves due to either traumatic injury or oncologic resection can create devastating functional deficits [1]. Even after repair, it can take months for regenerating axons to reach denervated target tissues when injuries are proximally located [1,4] This inability to rapidly restore the loss of function after axonal injury often results in poor clinical outcomes [5]. The availability of a surgeon with the requisite knowledge and experience to delicately perform the repair can be a significant limiting factor in some parts of the world and even our country For these reasons, we set out to develop a novel device/ system using suture-less coaptation for simple and effective nerve repair after injury including segmental nerve defects, in which any surgeon despite their specialty can promptly perform peripheral nerve repairs with positive outcomes and saving precious operative room time for other concomitant injuries that need more attention [7]. Creating a barbed sutureless coaptation device will provide a simple and standardized alternative to nerve repair decreasing donor’s morbidity
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