Development of a novel carrier optimized for cell sheet transplantation.

Yosuke Amagai,Jung Kyungsook,Kaoru Karasawa,Akane Tanaka,Masanori Kojima,Jun Watanabe,Hiroshi Matsuda,Akira Matsuda,Toyoji Hibi

doi:10.1080/21592535.2015.1027846

Yosuke Amagai, Jung Kyungsook + Show 7 more

Open Access

https://doi.org/10.1080/21592535.2015.1027846

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Abstract

Tissue engineering is a rapidly advancing technology in the field of regenerative medicine. For the transplantation of cell sheets, a carrier must maintain the shape of a cell sheet from a culture dish to affected sites as well as release the sheet easily onto the lesion. In this study, we examined the utility of a novel, poly(lactic acid)-based carrier for cell sheets transplantation to the cornea of dogs and the skin of rats. The poly(lactic acid)-based carrier easily picked a cell sheet up from the dish, fit to the shape of the transplantation sites, and saved time for cell sheets detachment comparing to a conventional carrier. Thus, the poly(lactic acid)-based carrier would be useful for easy cell sheet transplantations.

Highlights

For the transplantation of cell sheets, a carrier must maintain the shape of a cell sheet from a culture dish to affected sites as well as release the sheet onto the lesion
We examined the utility of a novel, poly(lactic acid)-based carrier for cell sheets transplantation to the cornea of dogs and the skin of rats
The poly(lactic acid)-based carrier would be useful for easy cell sheet transplantations

Summary

Introduction

We examined the utility of a novel, poly(lactic acid)-based carrier for cell sheets transplantation to the cornea of dogs and the skin of rats. The poly(lactic acid)-based carrier picked a cell sheet up from the dish, fit to the shape of the transplantation sites, and saved time for cell sheets detachment comparing to a conventional carrier. The poly(lactic acid)-based carrier would be useful for easy cell sheet transplantations.

Results

Conclusion