Abstract
To describe a new model of actinic enteritis that does not use radiotherapy machines. Sixteen Wistar rats were divided into four groups, consisting of four animals each: control (group A), two weeks after irradiation (group B), five weeks after irradiation (group C) and eight weeks after irradiation (group D). Animals were given a 10Gy radiation from a Cobalt-60 natural source in a nuclear technology research center. Protections of the surrounding tissues were obtained through the usage of plumb devices with a hole in the center, which served as a collimator. We obtained irradiated and non-irradiated colons from each animal. In group B we found an important inflammatory response in the irradiated colon, which appeared in a reduced way in group C and was minimal in group D, in which we found a relevant collagen submucosal deposition/fibrosis. In all groups, the non-irradiated colon had a lower pathological damage in comparison with the irradiated colon. We thus described an efficient and feasible technique for obtaining an animal model of actinic enteritis.
Highlights
Radiotherapy still plays a vital role in the management of pelvic malignancies
Studies involving radiation and its effects in animals are vast in the literature, mostly trying to determine drugs and means of preventing the damage caused by radiation[1]
The radiation technique is standardized in humans, we observed that there is no consensus in the experimental animal technique in diverse studies and variables such as the dose rate, the total dose, the fractioning scheme and the source unit change according to the researcher’s experience[2,3,4]
Summary
Its usage implies in several injuries in the surrounding organs and this damage accompanies patients throughout their lives. As more patients receive radiotherapy as part of their cancer treatment, and live longer, the incidence of radiotherapy complications continues to increase. Studies involving radiation and its effects in animals are vast in the literature, mostly trying to determine drugs and means of preventing the damage caused by radiation[1]. Most of the research available is based on radiation given by teletherapy machines. Those machines are used for the treatment of cancer patients and are usually unavailable (or of difficult access) for research purposes
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