Abstract
Pathophysiology of heart failure with preserved ejection fraction (HFpEF) is poorly understood today. One of the hypothesis is the role played by the endothelial dysfunction. To develop a murine model of HFpEF to study the role of EC dysfunction. We chose to develop a model that reproduce cardiovascular risk factors and co-morbidity seen in humans HFpEF by using aging, obese diabetic mice (db/db) perfused with Angiotensin II pump for one month (low grade inflammation). Males and females mice were studied at 1, 6 and 12 months by echocardiography, histology (parameters of EC dysfunction, fibrosis) and hemodynamic. At 1 and 6 months, we recorded no difference in cardiac functional, histologic and hemodynamic parameters in males db/db as compared to male db+. At 6 months females db/db displayed discrete echocardiographic and hemodynamic parameters of HFpEF as compared to female db+. Results at 12 months will be available for the meeting. Obese diabetic with low-grade inflammation mice do not develop clear markers of HFpEF within 6 months of life.
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