Abstract
BackgroundThe Health Utilities Index Mark 3 (HUI3) is a generic multi-attribute, preference-based system for assessing health-related quality of life. It is widely used overseas as an outcome measure and for estimating quality-adjusted life years. We aimed to estimate a multi-attribute and eight single-attribute utility functions for the HUI3 system based on community preferences in Japan. We conducted two preference surveys in this study. The first survey was designed to estimate a model of utility function and collect preference scores, and the second survey was designed to evaluate predictive validity of the utility function and provide independent scores. Values obtained from the feeling thermometer and standard gamble scores obtained from using a chance board were included in the preference scale. We recruited 1043 respondents (age: 20–79 years) from five cities in Japan through the general population classified by sex and age groups. Respondents were further randomly divided into a modeling group (n = 774) and a direct group (n = 263).ResultsWe acquired the estimation for eight single-attribute and a global multi-attribute utility function. The minimum expected multi-attribute utility score was − 0.002. The intraclass correlation coefficient between the directly measured utility score and the score generated by multi-attribute function in terms of 53 health conditions was 0.742.ConclusionsThe HUI3 scoring function developed in Japan has a strong theoretical and empirical basis. It will be useful in future to predict the directly measured score of health technology assessments in Japan.
Highlights
The Health Utilities Index Mark 3 (HUI3) is a generic multi-attribute, preference-based system for assessing health-related quality of life
The HUI3 is a generic multi-attribute, preferencebased system for assessing health-related quality of life (HRQL) [8] and comprises two complementary components [8, 9]: the first is a multi-attribute health-status classification system used to describe health status and the second is a multi-attribute utility function used to value the health status assessed through the multiattribute health-status classification system of the previous component
This study aimed to develop one multi-attribute and eight single-attribute utility functions for the HUI3 system based on community preferences in Japan in order to use the Japanese economic evaluation in accordance with the unique method
Summary
The Health Utilities Index Mark 3 (HUI3) is a generic multi-attribute, preference-based system for assessing health-related quality of life. It is widely used overseas as an outcome measure and for estimating qualityadjusted life years. We aimed to estimate a multi-attribute and eight single-attribute utility functions for the HUI3 system based on community preferences in Japan. Noto et al Journal of Patient-Reported Outcomes (2020) 4:23 recommends the use of the Health Utilities Index Mark 3 (HUI3) for estimating quality-adjusted life years. The HUI3 has been utilized to evaluate health conditions and HRQL of several patient groups with chronic diseases, and it is a reliable and relevant scale [10,11,12,13,14,15]
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