Abstract
The technique of molecular imprinting produces artificial receptor sites in apolymer that can be used in a biomimetic sensor. This research extends previous studies ofa molecularly imprinted polymer (MIP) biomimetic sensor for the small drug theophylline.The presence of theophylline in the biomimetic sensor was monitored by analyzing thepeak currents from cyclic voltammetry experiments. The functional working range of theMIP modified electrode was 2 - 4 mM theophylline. The concentration of theophyllinethat resulted in the best signal was 3 mM. The MIP sensor showed no response to thestructurally related molecule caffeine, and therefore was selective to the target analytetheophylline. This research will provide the foundation for future studies that will result indurable biomimetic sensors that can offer a viable alternative to current sensors.
Highlights
Novel sensors are needed for the detection and quantification of harmful compounds, such as toxins, and for beneficial compounds, such as drugs
The effect the rebinding of analyte to the molecularly imprinted polymer (MIP) has upon this reversible reaction is monitored through measurement by cyclic voltammetry
The MIP-Indium tin oxide (ITO) sensor was tested at four concentration levels with the target analyte, theophylline
Summary
Novel sensors are needed for the detection and quantification of harmful compounds, such as toxins, and for beneficial compounds, such as drugs. Imprinted polymers (MIPs) use the technique of biomimetics to create artificial receptor sites using specific monomers, the building blocks of polymers, to create tailored recognition sites for the target molecule. The polymer is considered imprinted because holes have been created that are specific in shape and size to the template, and to which only it can rebind. The sensitivity of the MIP-ITO sensor was evaluated by testing the response at 4 analyte concentrations: 1, 2, 3, and 4 mM. The response of each sensor to the analyte was compared to the baseline measurement This allowed the sensors to be compared and evaluated, and accounted for any slight differences in conductivity that may have been present between samples
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