Abstract
Summary Endometritis is a significant reproductive disease resulting in reduced fertility. Ovarian hormones are known to affect certain aspects of uterine defense mechanisms and this premise was used to develop a model of endometritis. Ovariectomized or reproductively intact mares were treated with dexamethasone (40mg), progesterone (150mg) or a combination of progesterone and dexamethasone to suppress uterine defense mechanisms. Mares were then inoculated intrauterinely with Streptococcus zooepidemicus. Mares were monitored for endometritis by complete reproductive evaluation on Days 3, 7, 14, 21, 35 and 49 following inoculation. All mares had significant infectious and inflammatory changes during the reproductive evaluation immediately after inoculation. These changes resolved within 14 days in mares treated with dexamethasone only. Mares treated with progesterone or a combination maintained uterine infection as long as progesterone was continued. Use of systemic progesterone throughout the experimental protocol allowed consistent development of endometritis in intact experimental mares. This established a uniform population of experimental mares for further research on the pathogenesis of and treatment for endometritis.
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