Abstract
Studies of in vitro release profiles are important during the development of drug delivery systems. This article describes the development and validation of a RP-HPLC method for the quantification of drug released from tamoxifen-loaded DSPE-PEG(2000)/TPGS micelles and the determination of the best dissolution medium and apparatus for this assay. The method showed specificity, linearity, precision, accuracy, and robustness for the parameters evaluated (range 0.25–20.0 µg mL−1). The best dissolution medium was 1.0 mol L−1 sodium salicylate, pH 7.4, and the most suitable apparatus was a PVC tube with one end covered with a dialysis membrane. This method was shown to be useful for tamoxifen quantification in in vitro release studies.
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callMore From: Journal of Liquid Chromatography & Related Technologies
Disclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
