Abstract
Background and aims: It is difficult to identify cancer-specific T cells in most malignancies as they are driven by patient-specific mutations. However, 80% of Merkel cell carcinoma (MCC) cases are driven by a polyomavirus (MCPyV). Importantly, the T cell immune response is focused on the short, almost invariant viral oncoproteins. Virus-driven MCC thus provides an opportunity to quantitatively characterize tumor-specific T cells. We developed specific tetramer reagents that bind T cell receptors (TCR) to identify tumor-reactive T cells.
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