Development of a low-energy particle irradiation facility for the study of the biological effectiveness of the ion track end

Abstract

Uncertainties surround the radiobiological consequences of exposure to charged particles, despite the increasing use of accelerated ion beams for cancer treatment (hadrontherapy). In particular, little is known about the long-term effects on normal tissue at the beam entrance or in the distal part of the Spread-Out Bragg Peak (SOBP). Moreover, although the relative biological effectiveness (RBE) of particle radiation has been traditionally related to the radiation linear energy transfer (LET), it has become increasingly evident that radiation-induced cell death, as well as long term radiation effects, is not adequately described by this parameter. Hence, exploring the effectiveness of various ion beams at or around the Bragg peak of monoenergetic ion beams can prove useful to gain insights into the role played by parameters other than the particle LET in determining the outcome of particle radiation exposures. In this context, the upgrade of the Tandem irradiation facility at Naples University here described, has allowed us to perform a series of preliminary radiobiological measurements using proton and carbon ion beams. The facility is currently used to irradiate normal and cancer cell lines with ion beams such as oxygen and fluorine.