Abstract
The present work deals with the development of a Love-wave biosensor for the diagnosis of the modification of cell viscosity. The relevant device performance such as insertion loss, attenuation, phase velocity, and sensitivity needs to be analysed as a function of the device structure and also regarding the effect of the liquid loading. In this study, we used an analytical model based on the equation of motions for a Love wave propagating in a three-layer structure. We show that the effect of the viscous coupling leads to insertion losses and a phase shift that impact the acoustic ratio. A comparison between experimental and theoretical results showed a good agreement between the behaviours as it was observed for the phase shift vs. the insertion loss with a limited difference in values (3.11/3.09—experimental/simulation for the sensitivity to the viscosity for different insertion losses) due to the assumptions made on the model used.
Highlights
Biosensors have found their place in today’s society, and this has been proven with the COVID-19 pandemic, which is why the biosensors market is expected to grow at a 7.5%compound annual growth rate (CAGR) during the forecast period of 2021–2026 [1].In the domain of the cell, it has been shown that their mechanical properties can differentiate normal cells from cancerous cones [2]
Based on the theoretical approach of Campbell and Jones [16] and McHale [14,20], we determined the dispersion curve and the sensitivity of our two layer systems made of a substrate (Quartz AT or LiNbO3 36YX) and a wave-guiding layer (ZnO)
Equation (7) to determine the mass sensitivity was obtained from Moreira et al [21]: 1 f0 d ρGL vGL dz z=−w where ρGL is the density of the guiding layer, and w is its thickness
Summary
Biosensors have found their place in today’s society, and this has been proven with the COVID-19 pandemic, which is why the biosensors market is expected to grow at a 7.5%. For a fluid in contact with the surface of the GL, L-SAW displays high sensitivity and propagates with very low loss since the acoustic energy is weakly transferred into the fluid. Due to this huge amount of possibilities to associate different substrates, guiding layers, and sensitive layers, it is of prime importance to be able to determine what choices should be made to obtain the best acoustic response considering the intended application. We present an analytical method that includes the fluid loading and the viscosity to model our layered structure in Love-wave configuration. We make a comparison between the experimental data and the simulation in order to understand the limitations of our model and to know its application framework
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