Abstract

Bioinformatics has been regarded as one of the rapidly-evolving fields with enormous impact on the history of life and biomedical sciences. It is an interdisciplinary science that integrates life sciences, mathematics and computer science in order to extract meaningful biological insights from large data sets of raw DNA and protein sequences. Our objective was the development of an entomogenomics database (provisionally named EntomDB) for education and research in entomology (entomology is the science of insects). This DB includes DNA/protein sequence data selected from genomes of major insect models of importance in biology and biomedical research. EntomDB will represent a customized easy, interactive and self- learning resource tool for beginner users in poor-resource settings. This will enable the users to learn basic skills in bioinformatics and genomics, needlessly to search through the numerous databases currently available on the World-Wide Web with their complex interfaces and contents. EntomDB will help students and young researchers in studying the primary structure, splicing, and translation and predict function of different genes by using simple simulation methods. It is also designed to be adaptable to work off-line, in case no internet connection is available. EntomDB is primarily designed for entomology discipline; however, it can easily be adapted for other disciplines in life and biomedical sciences. EntomDB will have important educational and developmental outcomes in promoting bioinformatics learning in the developing world and provide affordable first-level training for advanced degree and research levels.

Highlights

  • Bioinformatics and genomics are two of the modern life sciences that are rapidly evolving and changing the history of science

  • The training gene set and basic processes: Our local database, EntomDB includes information on DNA/protein sequences of different genes selected from major insect models

  • According to the central dogma of molecular biology (Fig. 2), the genetic material (DNA) present within the cell nucleus is firstly transcribed into messenger RNAs (mRNAs), which is transported into the cytoplasm to be translated into amino acids, the building unit of the proteins that will perform different cellular functions

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Summary

Introduction

Bioinformatics and genomics are two of the modern life sciences that are rapidly evolving and changing the history of science. It is an interdisciplinary science that strongly links life sciences, molecular biology, mathematics and computer science. It has been a powerful tool in the development of genomics and related sciences and a major tool for gaining new insights of biological data. Bioinformatics has become a crucial area of development and investment for major interest groups in Yasser M. Abd El-Latif 2Department of Mathematics, Faculty of Science, Ain Shams University, Cairo, Egypt academia, industry and governments, with multi-billion US dollars investments worldwide in Europe, USA and Asia [1], [2], [3], [4], [5]. Bioinformatics, as quoted from Hwa Lim [6]:

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