Abstract
The development of a reversed-phase liquid chromatographic method, using a mobile phase containing a mixture of anion and cation ion-pairing agents and a base-deactivated octyldecylsilyl column as stationary phase, is described for the control of all known impurities in ( Z)-chlorprothixene hydrochloride (bulk drug). Validation of the method showed it to be reproducible, selective for both ( Z) chlorprothixene hydrochloride and its E-isomer, accurate and linear over the concentration range of analysis with a limit of detection of 0.3 μg ml −1.
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