Abstract
Physiologically Based Pharmacokinetic (PBPK) models can be used to determine the internal dose and strengthen exposure assessment. Many PBPK models are available, but they are not easily accessible for field use. The Agency for Toxic Substances and Disease Registry (ATSDR) has conducted translational research to develop a human PBPK model toolkit by recoding published PBPK models. This toolkit, when fully developed, will provide a platform that consists of a series of priority PBPK models of environmental pollutants. Presented here is work on recoded PBPK models for volatile organic compounds (VOCs) and metals. Good agreement was generally obtained between the original and the recoded models. This toolkit will be available for ATSDR scientists and public health assessors to perform simulations of exposures from contaminated environmental media at sites of concern and to help interpret biomonitoring data. It can be used as screening tools that can provide useful information for the protection of the public.
Highlights
Default consumption values of air, water, soil, and foods are often used to estimate exposures to environmental pollutants from different routes of exposure
This article focuses on the project achievements to date, including the recoding of human Physiologically based pharmacokinetic (PBPK)/PK volatile organic compounds (VOCs) and metal models [9,10,11]
Assessment of our generic VOCs PBPK model was first performed by comparison of the published human kinetic data for each VOC and our recoded version of the published model
Summary
Default consumption values of air, water, soil, and foods are often used to estimate exposures to environmental pollutants from different routes of exposure. Based pharmacokinetic (PBPK) models are being used to duplicate biological and physiological processes These models may increase the accuracy of calculating the internal dose in tissues by use of such measures as blood or urine levels [1,2,3]. Berkeley, CA, USA for simulation and optimization because of its ease of application, economical multi-user license, and faster compilation properties [8] This toolkit will assist researchers and risk assessors to assess potential chemical health effects. These models are not intended to be state-of-the-art models with metabolites or the latest version of a PBPK model. This article focuses on the project achievements to date, including the recoding of human PBPK/PK VOCs and metal models [9,10,11]
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