Development of a high intensity focused ultrasound (HIFU) hydrophone system

Abstract

In the past few years, High Intensity Focused Ultrasound (HIFU) has developed from a scientific curiosity to an accepted therapeutic modality. Concomitant with HIFU's growing clinical use, there has been a need for reliable, economical and reproducible measurements of HIFU acoustic fields. A number of approaches have been proposed and investigated, most notably by Kaczkowski et al (Proc. 2003 IEEE Ultrasonics Symposium, 982-985). We are developing a similar reflective scatterer approach, incorporating several novel features which improve the hydrophone's bandwidth, reliability, and reproducibility. For the scattering element, we have used a fused silica optical fiber with a polyamide protective coating. The fused silica core is 73 microns in diameter with a 5 micron thick polyamide coating for a total diameter of 83 microns. The fiber was prepared by cleaving to yield a perpendicular/flat cut. The fiber is maintained in position using a capillary tube arrangement which provides structural rigidity with minimal acoustic interference. The receiver is designed as a segmented, truncated spherical structure with a 10cm radius; the scattering element is positioned at the center of the sphere. Each segment is approximately 6.3 cm square. The receiver is made from 25 micron thick, biaxially stretched PVDF, with a Pt-Au electrode on the front surface. Each segment has its own high impedance, wideband preamplifier, and the signals from multiple segments are summed coherently. As an additional feature, the system is designed to pulse the PVDF elements so that the pulse-echo response can be used to align the fiber at the center. This is important when the need arises to change the fiber due to, for instance, cavitation damage. The hydrophone can also be designed with a membrane structure to allow the region around the scatterer to be filled with a fluid which suppresses cavitation. Initial tests of the system have demonstrated a receiver array sensitivity of -279 dB re 1 microVolt/Pa (before preamplification), with a scattering loss at the fiber of approximately 39dB, producing an effective sensitivity of -318 dB re 1 microVolt/Pa. The addition of the closely coupled wideband preamplifiers boosts the signal to a range which is sufficient for the measurement of HIFU transducers. The effective bandwidth of the system exceeds 15MHz, through careful design and the use of PVDF as a sensor material. In order to test the system, a HIFU transducer in the 4.0MHz frequency range was tested at low output settings using a conventional PVDF membrane hydrophone. The prototype system was then used to characterize the same HIFU transducer at full power. The results showed good correlation between waveforms and cross-axis beam measurements, taking into account the additional shock losses at higher output settings.