Abstract
Regeneration-promoting vascular substitutes such as pro-healing stents or vascular grafts could minimise the incidence of thrombosis, restenosis and other events leading to device failure. One strategy to promote endogenous repair mechanisms is to functionalise the surfaces of the vascular graft with peptides or proteins that capture circulating endothelial progenitor cells (EPCs). EPCs are circulating CD34+ bone marrow-derived cells that could have a significant impact on endothelialisation due to high proliferative and regenerative potential. Previous studies have tested surface-immobilised antibodies to capture EPCs, as well as surface-immobilised extracellular matrix-derived peptides to promote adhesion and expansion. However, these strategies have not been tested in combination. We hypothesise that the co-immobilisation of peptides and antibodies could maximise endothelialisation by targeting both the EPC capture and expansion steps.
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
