Abstract
In recent years, studies using ultrasound energy for cancer treatment have advanced, thus revealing the enhancement of drug effects by employing low-intensity ultrasound. Furthermore, anti-angiogenesis against tumors is now attracting attention as a new cancer treatment. Therefore, we focused on the biological effects and the enhancement of drug effects brought by this low-intensity ultrasound energy and reported on the efficacy against a uterine sarcoma model, by implementing the basic studies, for the first time, including the concomitant use of low-intensity ultrasound irradiation, as an expected new antiangiogenic therapy for cancer treatment. Furthermore, we have succeeded in simultaneously utilizing low-intensity ultrasound in both diagnosis and treatment, upon real time evaluation of the anti-tumor effects and anti-angiogenesis effects using color Doppler ultrasound imaging. Although the biological effects of ultrasound have not yet been completely clarified, transient stomas were formed (Sonoporation) in cancer cells irradiated by low-intensity ultrasound and it is believed that the penetration effect of drugs is enhanced due to the drug being more charged inside the cell through these stomas. Furthermore, it has become clear that the concomitant therapy of anti-angiogenesis drugs and low-intensity ultrasound blocks the angiogenic factor VEGF produced by cancer cells, inhibits the induction of circulating endothelial progenitor cells in the bone marrow, and expedites angiogenic inhibitor TSP-1. Based on research achievements in recent years, we predict that the current diagnostic device for color Doppler ultrasound imaging will be improved in the near future, bringing with it the arrival of an age of “low-intensity ultrasound treatment that simultaneously enables diagnosis and treatment of cancer in real time.”
Highlights
Japan is among the countries with the longest life expectancies in the world, we have reached an age in which malignant tumors develop in approximately one of every two people, with approximately one in three people dying of malignant tumors
We focused on the biological effects and enhancement of drug effects brought by this low-intensity ultrasound energy, implementing basic studies, for the first time, through the concomitant use of low-intensity ultrasound irradiation as an expected new antiangiogenic therapy for cancer treatment
The difference in intratumoral blood flow by color Doppler imaging among each group was immunohistochemically proven by the chromosomes of vascular endothelial growth factor (VEGF) protein and the chromosomes of tumor vascular endothelial cells, using
Summary
Japan is among the countries with the longest life expectancies in the world, we have reached an age in which malignant tumors develop in approximately one of every two people, with approximately one in three people dying of malignant tumors. Due to the development of basic studies in recent years, the enhancement of drug effects by low-intensity ultrasound has been revealed as almost certain. We focused on the biological effects and enhancement of drug effects brought by this low-intensity ultrasound energy, implementing basic studies, for the first time, through the concomitant use of low-intensity ultrasound irradiation as an expected new antiangiogenic therapy for cancer treatment. We would like to recommend the further development of an effective and minimally invasive cancer treatment which simultaneously enables diagnosis and treatment of cancer in real time, by applying low-intensity ultrasound energy
Sign-in/Register to view highlights & summary Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
