Abstract
Engineered tissue production necessitates a good understanding of physiopathological mechanisms behind regulation of the cell function. In vivo, the functions of cardiac cells are controlled by a precise combination of electrical and mechanical stimulations. So, we hypothesize that cardiac cells in vitro need to grow in a controlled environment incorporating electrical and mechanical stimulations for optimized physiological functions. As a first step, we focus on the effects of cultivating cardiac cells on the elastic membrane through which mechanical stimulation is transferred to cells.
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