Abstract
BackgroundIt has been proposed that in the absence of a blood supply, the ocular lens operates an internal microcirculation system. This system delivers nutrients, removes waste products and maintains ionic homeostasis in the lens. The microcirculation is generated by spatial differences in membrane transport properties; and previously has been modelled by an equivalent electrical circuit and solved analytically. While effective, this approach did not fully account for all the anatomical and functional complexities of the lens. To encapsulate these complexities we have created a 3D finite element computer model of the lens.MethodsInitially, we created an anatomically-correct representative mesh of the lens. We then implemented the Stokes and advective Nernst-Plank equations, in order to model the water and ion fluxes respectively. Next we complemented the model with experimentally-measured surface ionic concentrations as boundary conditions and solved it.ResultsOur model calculated the standing ionic concentrations and electrical potential gradients in the lens. Furthermore, it generated vector maps of intra- and extracellular space ion and water fluxes that are proposed to circulate throughout the lens. These fields have only been measured on the surface of the lens and our calculations are the first 3D representation of their direction and magnitude in the lens.ConclusionValues for steady state standing fields for concentration and electrical potential plus ionic and fluid fluxes calculated by our model exhibited broad agreement with observed experimental values. Our model of lens function represents a platform to integrate new experimental data as they emerge and assist us to understand how the integrated structure and function of the lens contributes to the maintenance of its transparency.
Highlights
It has been proposed that in the absence of a blood supply, the ocular lens operates an internal microcirculation system
Values for steady state standing fields for concentration and electrical potential plus ionic and fluid fluxes calculated by our model exhibited broad agreement with observed experimental values
The lens is not a purely passive optical element and its structure and optical properties need to be actively maintained. It has been proposed by Mathias et al [2] that in the absence of a blood supply, the lens operates an internal microcirculation system
Summary
It has been proposed that in the absence of a blood supply, the ocular lens operates an internal microcirculation system This system delivers nutrients, removes waste products and maintains ionic homeostasis in the lens. The lens is not a purely passive optical element and its structure and optical properties need to be actively maintained It has been proposed by Mathias et al [2] that in the absence of a blood supply, the lens operates an internal microcirculation system. This system delivers nutrients, removes wastes and maintains the ionic homeostasis of the lens [3,4]. This system is critical for maintaining the optical properties of the lens
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