Abstract
X-chromosomal short tandem repeat (X-STR) loci can play increasingly important roles in some complex kinship cases. In our paper, 360 samples (191 males and 169 females) unrelated individuals from Guangdong province were successfully genotyped using a new multiplex PCR system which can co-amply 12 X-STR markers (GATA172D05, DXS6789, DXS10074, DXS10078, GATA165B12, DXS6797, DXS6803, DXS6804, GATA31E08, DXS7130, DXS9895 and DXS6810). 110 alleles were observed totally. Hardy–Weinberg equilibrium tests showed no significant deviation for all of the 12 X-STR loci. DXS6789–GATA165B12 and DXS7130–DXS9895 were found to be in linkage disequilibrium. The results show that the 12-plex X-STR multiplex system is highly polymorphic and sensitive. It may be useful for forensic personal identification, paternity testing, especially for the kinship testing.
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