Abstract
Herein, novel drug-eluting, bio-absorbable scaffold intended to cover piercing studs is introduced. This “biopierce” will stay in human tissue following piercing, and will slowly release an antimicrobial agent to prevent infection while the wound heals. Nearly 20% of all piercings lead to local infection. Therefore, it is imperative to develop alternative methods of piercing aftercare to prevent infection. Biopierces were made using mupirocin loaded poly-lactic-co-glycolic acid (PLGA) biomaterial ink, and a low-temperature 3D printing technique was used to fabricate the biopierces. Proton nuclear magnetic resonance (1H NMR) spectroscopy was used to confirm the complete removal of the solvent, and liquid chromatography high-resolution mass spectrometry (LC-HRMS) was used to confirm the structural integrity of mupirocin and to quantify the amount of the released drug over time. The efficacy of the biopierces against Staphylococcus aureus, one of the most common piercing-site pathogens, was confirmed over two weeks using in vitro antimicrobial susceptibility testing.
Highlights
Body piercing has become very popular in the past two decades, and it has been reported that approximately 50% of millennials receive at least one non-earlobe piercing [1,2]
As compared to the wounds stemming from the piercing of soft tissue, cartilage piercings have a greater predisposition to complications [9,10]. These complications are due to the detachment of perichondrium and microfractures of the cartilage during piercing, which leads to edema and bleeding into the cartilage [10]
Great strides have been achieved in the field of active drug-eluting wound dressings, the release kinetics of drugs and bioactive compounds must be improved in terms of sustained and prolonged release to be used for piercing aftercare applications
Summary
Body piercing has become very popular in the past two decades, and it has been reported that approximately 50% of millennials receive at least one non-earlobe piercing [1,2]. Yank et al developed an electrospun wound dressing [29]; 90% of the loaded antibiotic was released during the first 30 min of in vitro study. Great strides have been achieved in the field of active drug-eluting wound dressings, the release kinetics of drugs and bioactive compounds must be improved in terms of sustained and prolonged release to be used for piercing aftercare applications. There is a need to develop alternative low-temperature 3D printing methods for the fabrication of constructs that provide a prolonged drug release for piercing infection prevention. A drug-eluting bio-absorbable scaffold was developed and is intended to cover piercing studs This “biopierce” will stay in human tissue following piercing for up to two weeks and to prevent the development of a wound infection. The release profile of varying grades (lactic to glycolic ratios) of PLGA and concentration of mupirocin is characterized over two weeks
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