Abstract
Objective: The objective was to develop buccal patches of an antihypertensive drug and losartan potassium using jackfruit polymer for sustained buccal delivery.
 Methods: The patches were prepared by the solvent casting method. Five formulations were developed with varying concentrations of jackfruit polymer. USP type II apparatus was used to perform in-vitro release study under perfect sink condition. Buccal formulations were developed to a satisfactory level in terms of drug release, bioadhesive strength, content uniformity, moisture content, surface pH, thickness, and stability study.
 Results: From the results obtained F5 was found as best formulation, having appropriate folding endurance greater than 300, moisture content of 1.14±0.03 percentage (%), moisture uptake of 6.21±0.12%, swelling index (62.78%), bioadhesion strength (37.62±0.25 g), and bioadhesion time of 9 h 5 min. Fourier-transform infrared spectroscopy studies have shown no interactions between drug and polymer. All the formulations followed zero-order kinetics.
 Conclusion: It can be concluded that mucoadhesive buccal patches of losartan potassium using jackfruit polymer are an auspicious dosage form to prolong the release of drug and enhance its poor oral bioavailability.
Highlights
Mucoadhesion is a process of attachment between two materials such as mucosal membrane and mucoadhesive polymer for a protracted period
Identification of drug and drug-polymer interaction study The infrared spectroscopy (IR) spectrum of the drug alone and in combination with jackfruit mucilage, ethylcellulose, and HPMC K100M suggested that the characteristic peak of the drug was undisturbed and the characteristic peak of the polymer was unaffected
The IR study indicates that drugs were in the free form and no drug-polymer and polymer-polymer interaction took place during formulation development
Summary
Mucoadhesion is a process of attachment between two materials such as mucosal membrane and mucoadhesive polymer for a protracted period. The delivery of drugs through the buccal route gives direct entry to the systemic circulation through the jugular vein; thereby, it bypasses first-pass metabolism and degradation of the drug in the acidic environment of the gastrointestinal tract so that the drug’s bioavailability gets enhanced [1,2]. In this modern epoch, lots of mucoadhesive devices have been developed. Buccal patches provide greater flexibility and comfort than buccal tablets It can occupy on mucosa for more time compared to gels. It should possess sufficient mucoadhesive strength; thereby, it will keep hold in the mouth for a prolonged duration [3]
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More From: Asian Journal of Pharmaceutical and Clinical Research
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