Abstract
Abstract This research focuses on the synthesis and adhesive properties of mucoadhesive mats, prepared with poly(vinylic alcohol) as a base polymer for the oromucosal release of propranolol (PRO) by the electrospinning technique. The nanofibers mats were evaluated by scanning electron microscopy (SEM), Fourier-transform infrared spectroscopy, thermogravimetric analysis, and differential scanning calorimetry; in vitro drug entrapment efficiency, degradation time, and adhesion studies were performed. SEM images of the electrospun mats show the correct formation of fibers with a variable diameter and porosity. Thermal studies indicate excellent thermal stability of the scaffolds, The fibrous mats loaded with 10% of the drug exhibit the best thermal stability with decomposition after 450°C. In vitro studies indicate a drug content of 88% loaded in the mats. In the cytotoxicity test, loaded mat presents cell proliferations of 97% and 88% for drug concentrations of 10% an 15%, respectively. To conclude, the formed electrospun adhesive mats exhibited excellent thermal stability, adhesive properties, and drug entrapment efficiency, promising features for a successful drug topical release system on mucosal tissue in the oral cavity.
Highlights
Hemangiomas in children are the most common group of benign tumors in infancy due to uncontrolled reproduction of endothelial cells, producing permanent esthetic deformations, and in serious cases affecting vital functions [1,2,3].Treatment is individualized, depending on morphology, size, localization, and growth rate of the lesion
Human fibroblast HFF-1 cells (ATCC- SCRC-1401) were purchased from the American Type Culture Collection (ATCC), Dulbecco’s modified Eagle’s medium (DMEM) and fetal bovine serum (FBS) were from BenchMark, Gemini Bio Products, and penicillin-streptomycin was purchased from Sigma-Aldrich
To create the electrospun scaffolds, PRO was added to the poly(vinyl alcohol) (PVA) base solution; subsequently, electrospinning parameters were optimized to obtain adequate features for the polymer blends, 10% and 15%
Summary
Hemangiomas in children are the most common group of benign tumors in infancy due to uncontrolled reproduction of endothelial cells, producing permanent esthetic deformations, and in serious cases affecting vital functions [1,2,3].Treatment is individualized, depending on morphology, size, localization, and growth rate of the lesion. Several treatments have been used orally, such as corticoids, and others such as interferon, timolol and propranolol (PRO) intravenously [4,5]. PRO is the most studied therapeutic option in recent years, thanks to the fact that it has been effective in cutaneous, hepatic, and respiratory tract hemangiomas, both before and after the proliferative phase [6,7]. PRO, a non-selective beta (β)-blocker, has been used orally or intravenously for the treatment of high blood pressure, hemangiomas, migraine headaches, and to prevent future heart problems in those with angina pectoris, among others [8,9]. PRO was proposed as a firstline treatment due to its effectiveness, low cost, and safety in pediatric use [10,11,12]
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