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Abstract
Acne is an inflammatory condition in the pilosebaceous glands due to many factors, including colonization of Propionibacterium acnes. White tea and pomegranate seed oil (PSO) contain many phytochemical constituents with antibacterial properties. This study aims to develop emulgel preparations containing white tea extract and PSO with good physical characteristics and stability. The study was also conducted to determine the antibacterial activity of extracts and emulgel preparation against the acne-causing bacteria P. acnes. White tea was extracted using 70% ethanol by ultrasonic extraction method. Antibacterial activity tests were conducted using agar well diffusion. Emulgels were prepared using PSO as the oil phase, stearic acid and triethanolamine (TEA) as the emulsifier agent, and viscolam mac 10 as a gelling agent. The emulgels were evaluated by organoleptic, pH, viscosity, spreadability, centrifugation, and freeze-thaw tests. The white tea extract has potent antibacterial activity against P. acnes with a MIC value of 0.05%. The extract at 1% and 2% concentrations has been successfully developed into an emulgel system with good physical characteristics based on organoleptic, pH, viscosity, and spreadability tests. The emulgel was stable base on the centrifugation and freeze-thaw tests. Emulgel containing 2% white tea extract has optimum antibacterial activity with an inhibition zone of 12.80 ± 0.20 mm, The white tea emulgel has potent antibacterial activity and can be further developed as anti-acne product
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