Abstract
The aim of present study was to develop and validate new simple, easy , selective , precise and accurate reverse phase high performance liquid chromatography for the estimation of Felodipine i n bulk and pharmaceutical dosage f orm. The separation was carried on HPLC system consisting C - 18 column (150 x 4.6 mm, 5 μm) at room temperature coupled with a guard column of silic a with flow rate 1 ml/min. The mobile phase used was Acetonitrile: Water in the ratio 70:30. T he drug was detected using UV - Vis detector at the wavelength of 238 nm and the run time was 10 min utes . The retention time was 8.29 minutes. The percentage RSD for precision and accuracy of the method was found to be less than 2 %. The method was validated as per ICH guidelines. The proposed method was fou nd to be accurate, repeatable and consistent. It wa s effectively applied for the analysis of the drug in marketed formul ation and could be used for the regular analysis of formulation containing the Felodipine .
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
