Abstract
New, simple and cost effective UV-spectrophotometric method was developed for the estimation of orbifloxacin in pharmaceutical formulation. Orbifloxacin was estimated at 290 nm in 0.5 M hydrochloric acid. Linearity range was found to be 1.0-6.0 μg mL-1. The method was tested and validated for various parameters according to main guidelines. The proposed method was successfully applied for the determination of orbifloxacin in tablets. The results demonstrated that the procedure is accurate, precise and reproducible, while being simple, economical and less time consuming. It can be suitably applied for the estimation of orbifloxacin in routine quality control and dissolution studies.
Highlights
The fluoroquinolones are a class of compounds that comprise a large and expanding group of synthetic antimicrobial agents
Fluoroquinolones have become an important group, for the treatment of infections caused by more conventional antibiotic-resistant bacteria (Haines et al, 2001)
The solutions were prepared in 0.5 M hydrochloric acid
Summary
The fluoroquinolones are a class of compounds that comprise a large and expanding group of synthetic antimicrobial agents. Orbifloxacin (Figure 1, CAS: 113617-63-3), namely 1-cyclopropyl-5,6,8-trifluoro1,4-dihydro-7-(cis-3,5-dimethyl-1-piperazinyl)-4oxoquinoline-3-carboxylic acid, is a new third-generation fluoroquinolone antibacterial drug, developed mainly for the treatment of gastrointestinal and respiratory infections in animals (Nakamura, 1995; Matsumoto et al, 1999a,b; Martinez, McDermott, Walker, 2006). It is used for the treatment of skin, soft tissue and urinary tract infections. Fluoroquinolones have become an important group, for the treatment of infections caused by more conventional antibiotic-resistant bacteria (Haines et al, 2001).
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