Abstract
Introduction: Modern analytical chemistry is heading to the side of the “Green Chemistry” approach. The implementation of the current approach is in the development of fast analytical methods that combine the determination of several compounds with the utilization of methods that do not generate wastes of organic solvents. Aim: The aim of the current work was to develop a method for the simultaneous determination of benzydamine hydrochloride (API) and methyl parahydroxybenzoate (preservative) in the dosage form. Materials and Methods: The development and validation of the proposed methodology were carried out. Results and Discussion: The validation parameters were determined; it was shown that the technique is robust, specific to determinable analytes. Conclusion: The developed technique can be used in control laboratories for the simultaneous determination of benzydamine hydrochloride and methyl parahydroxybenzoate in the finished dosage form of benzydamine.
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