Abstract
The objective of the present research work was to develop an innovative, simple, and economic method for estimation of Vilazodone in bulk and dosage form by RP-HPLC. The chromatographic conditions were performed on Phenomenex Luna C18, 100A, 5µm, 250mm x 4.6mm i.d.as stationary phase and mobile phase was prepared with a mixture of Phosphate Buffer: Acetonitrile = 30:70 (pH-7.6) flow 1.0ml/min, with Injection Volume 20µl, at detection wavelength 238nm and run time at 8.0 min.The analytical method is validated for estimation of vilazodone over a range of 06µg/ml–16µg/ml. The results of system suitability test, linearity, precision and accuracy, robustness, specificity, LOD and LOQ and stabilities presented in this report are within the acceptance range.A specific, sensitive, economic method estimation of vilazodone has been developed based on ICH Guidelines with bulk and dosage forms.
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