Abstract
A stability indicating HPTLC method was developed and validated for the determination of levosulpiride in tablet dosage form using mobile phase consisting of ethyl acetate : methanol : toluene : triethylamine (4.5 : 3.5 : 2 : 0.2v/v/v/v) and detection was carried out at 238 nm. Linearity was observed over the concentration range 100-500 ng/spot. Levosulpiride was subjected to stress conditions including acidic, alkaline, oxidation and photolytic degradation. Levosulpiride is more sensitive towards alkaline degradation. The method was validated as per ICH guidelines. The content of levosulpiride in marketed formulation was found to be 99.13 %±0.38 of labelled amount. The proposed method was found to be reliable, reproducible and specific for the estimation of levosulpiride in tablet dosage form.
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