Abstract
Rapid, sensitive, cost effective and reproducible stability-indicating derivative spectrophotometric methods have been developed for the estimation of dronedarone HCl employing peak–zero (P–0) and peak–peak (P–P) techniques, and their stability-indicating potential assessed in forced degraded solutions of the drug. The methods were validated with respect to linearity, accuracy, precision and robustness. Excellent linearity was observed in concentrations 2–40 μg/ml (r 2 = 0.9986). LOD and LOQ values for the proposed methods ranged from 0.42–0.46 μg/ml and 1.21–1.27 μg/ml, respectively, and excellent recovery of the drug was obtained in the tablet samples (99.70 ± 0.84%).
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