Abstract
Abstract: A simple and accurate simultaneous method was developed for tetracycline hydrochloride (TH) and clotrimazole with a mixture of solvents. the combination is used to Validate the developed UV-spectrophotometric method as per ICH guidelines, The concentration of Tetracycline hydrochloride & clotrimazole in the sample solution was determined by solving the respective simultaneous equations generated by using absorptivity coefficients and absorbance values of TH & Clotrimazole at these wavelengths 361 nm and 259 nm respectively. and both satisfy Beer's law in concentration ranges of 4-20 µg/ml for TH and 10- 30 µg/ml for Clotrimazole. The method was effectively used to estimate TH and clotrimazole in Buccal film without the interference of common excipients.
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