Abstract
Sulfadoxine and pyrimethamine are often formulated together and used in the treatment of malaria especially in pregnant women serving as a prophylaxis. A new simple, precise and accurate reverse-ph...
Highlights
Malaria is the world’s most common parasitic infection in the tropics and it is ranked among the major health issues affecting most developing countries (Rao, Krishna, Kumar, & Venkateswarlu, 2011)
Acetonitrile (HPLC grade) from Carlo Erba (Rodano, Italy), Potassium dihydrogen orthophosphate and phosphoric acid were obtained from Sigma-Aldrich (St Louis, MO, USA)
Acetonitrile: phosphate buffer (75:25, v/v), pH 2.5, was chosen because it produced well-resolved peaks with the two active pharmaceutical ingredients (APIs) eluting under 4 min
Summary
Malaria is the world’s most common parasitic infection in the tropics and it is ranked among the major health issues affecting most developing countries (Rao, Krishna, Kumar, & Venkateswarlu, 2011). Because of its severe effect on humans (Lewison & Srivastava, 2008), several antimalarial drugs have been produced in an attempt to help control this deadly disease. Among these are chloroquine, quinine, camoquine and combinational drugs like artemether-lumefantrine, sulfadoxine-pyrimethamine and artesunate-amodiaquine. One major challenge facing malaria control is the ability of the parasites to develop resistance to the antimalarial drugs produced (Rao et al, 2011). A fixeddose combination of sulfadoxine-pyrimethamine (SP) has been used to replace the resisted antimalarial drugs (Raveendra, Vemula, & Sharma, 2013) since it is efficacious and has fewer side effects (Garner & Brabin, 1994). Some of the antimalarial drugs on the market are sub-standard and has serious implications on human health (Mbinze et al, 2015)
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