Abstract
Abstract Background: Curcumin and quercetin are the two important flavonoids that are being used as food ingredients across the globe. They also possess many pharmacological activities such as anti...
Highlights
Curcumin and quercetin are the two important flavonoids that have gained consideration in the last 30 years for their antidiabetic, antioxidant, and anti-inflammatory effects
System suitability parameters such as theoretical plate number, tailing factor, resolution between curcumin and quercetin peaks, and height equivalent to theoretical plate (HETP) for both drugs were calculated by injecting a blank mobile phase followed by six replicates of 250 ng curcumin–quercetin mixture onto the high-performance liquid chromatography (HPLC) system.[34]
Drug loading of developed self-nano emulsifying drug delivery system (SNEDDS) formulation loaded with curcumin and quercetin was evaluated using this simultaneous method
Summary
Curcumin and quercetin are the two important flavonoids that have gained consideration in the last 30 years for their antidiabetic, antioxidant, and anti-inflammatory effects. Several clinical and preclinical studies have shown the potential effect of these two flavonoids in the treatment of different diseases such as arthritis,[1] diabetes,[2,3] cancer,[3] cardiovascular diseases,[4,5] and bacterial infections.[6,7] Numerous actions of curcumin are linked to its various activities on the glycogen synthase kinase 3-beta (GSK-3b) pathway.[8] Mechanisms of action of quercetin are pleiotropic and involve the inhibition of intestinal glucose absorption, insulin secretory, and insulin-sensitizing activities as well as improved glucose utilization in peripheral tissues.[9,10] both the drugs act on different pathways that are involved in diseases such as diabetes, cancer, neurodegenerative a Rubiya Khursheed, Sachin Kumar Singh, Bhupinder Kapoor, Monica Gulati, Sheetu Wadhwa, Saurabh Gupta, Parteek Prasher, Deepak Kumar, Kamal Dua, L.
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