Abstract
IntroductionWorld Health Organization (WHO) Grade III meningioma is a central nervous system tumor with a poor prognosis. In this retrospective cohort study, the authors constructed a nomogram for predicting the prognosis of WHO Grade III meningioma.MethodsThe patients of this nomogram were based on the Surveillance, Epidemiology, and End Results (SEER) database between 2000 and 2018. All patients were randomly divided into a development cohort (964 patients) and a validation cohort (410 patients) in a 7:3 ratio. The least absolute shrinkage and selection operator (LASSO) regression was used to screen the predictors. The Cox hazards regression model was constructed and the prognosis was visualized by nomogram. The performance of the prognostic nomogram was determined by consistency index (C-index), clinical net benefit, and calibration.ResultsEight variables were included in the nomogram: gender, race, age at diagnosis, histology, tumor site, tumor size, laterality, and surgical method. The C-index of the training set and verification set were 0.654 and 0.628. The calibration plots showed that the nomogram was in good agreement with the actual observation. The clinical decision curve indicates that the nomogram has a good clinical net benefit in WHO Grade III meningioma.ConclusionsA prognostic nomogram of a large cohort of WHO Grade III meningioma was established and verified based on the SEER database. The nomogram we established may help clinicians provide personalized treatment services and clinical decisions for patients.
Highlights
World Health Organization (WHO) Grade III meningioma is a central nervous system tumor with a poor prognosis
A total of 1442 patients were diagnosed with WHO Grade III meningioma from 2000 to 2018 in the SEER database. 1374 patients were included in the analysis
Previous studies have suggested that age is an influential factor for the prognosis of patients with meningioma [11], so we divided the age into three levels according to 0-19 years old, 20-59 years old, and 60+ years old
Summary
World Health Organization (WHO) Grade III meningioma is a central nervous system tumor with a poor prognosis. In this retrospective cohort study, the authors constructed a nomogram for predicting the prognosis of WHO Grade III meningioma. According to the 2016 edition of the World Health Organization (WHO) Central nervous system classification criteria, WHO Grade III meningioma include papillary meningioma, rhabdoid meningioma, and anaplastic meningioma [2]. Some studies have shown that the average survival time of WHO Grade III meningioma is about 3 years [4, 5]. It is very necessary to accurately predict the survival time of WHO Grade III meningioma patients, but there is no effective prediction tool. An effective and accurate prediction model needs to be developed to help clinicians provide individualized treatment for patients with meningioma
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