Abstract
BackgroundPrimary peritoneal serous carcinoma (PPSC) is a rare tumor that lacks a prognostic prediction model. Our study aims to develop a nomogram to predict overall survival (OS) of PPSC patients.MethodsPatients confirmed to have PPSC between 2004 and 2012 were selected from the Surveillance, Epidemiology, and End Results (SEER) database. LASSO and multivariate Cox regression analyses were used to screen for meaningful independent prognostic factors to construct a nomogram model for 3-, 5-, and 10-year OS among patients with PPSC. The nomogram compared the discrimination, calibration, and net benefits with the International Federation of Gynecology and Obstetrics (FIGO) staging system of PPSC patients.ResultsEight variables were selected to establish the nomogram for PPSC. The established nomogram performed significantly better than the FIGO staging system (p < 0.05). The 3-, 5-, and 10-year OS of PPSC was 0.498, 0.306, and 0.152, respectively. Patients of old age, widowed marital status, grade high, FIGO IIIB, IIIC, or IV, lymph node metastasis, no lymphadenectomy, no surgery, and no chemotherapy got higher score which corresponds with higher risk and lower OS. In the multivariate Cox regression analysis, age, histological grade, FIGO staging, lymph node metastasis, and lymphadenectomy (four or more) were identified as independent prognostic factors for PPSC.ConclusionsPPSC patients have distinct characteristics with respect to their presentation and survival outcomes. A prognostic nomogram constructed by various clinical indicators can provide better and more accurate predictions for patients with PPSC.
Highlights
Primary peritoneal cancer (PPC) is a kind of extraovarian malignant tumor that widely distributes in the peritoneal cavity, mainly on the surface of the omentum and peritoneum with intact ovaries or minimal ovarian involvement [1]
There is no standard treatment for Primary peritoneal serous carcinoma (PPSC) while it is traditionally treated in a similar way to stage III/IV epithelioid ovarian serous carcinoma, including maximum surgical removal of peritoneal deposits followed by platinum/taxane chemotherapy regimens [6, 7]
The exclusion criteria were as follows [1]: missing information on race, marital status, histological grade, lymph node status, Federation of Gynecology and Obstetrics (FIGO) staging system based on the American Joint Committee on Cancer (AJCC) TNM staging system, surgery type, lymphadenectomy, or chemotherapy [2]; patients died within 1 month or were followed up less than 1 month since initial diagnosis
Summary
Primary peritoneal cancer (PPC) is a kind of extraovarian malignant tumor that widely distributes in the peritoneal cavity, mainly on the surface of the omentum and peritoneum with intact ovaries or minimal ovarian involvement [1]. Primary peritoneal serous carcinoma (PPSC) approximately accounting for 90% of PPC, is histologically, molecularly, and clinically similar to stage III/IV epithelioid ovarian serous carcinoma [5]. There is no standard treatment for PPSC while it is traditionally treated in a similar way to stage III/IV epithelioid ovarian serous carcinoma, including maximum surgical removal of peritoneal deposits followed by platinum/taxane chemotherapy regimens [6, 7]. The survival rate of patients with PPSC is similar to or 2 to 6 months less than that of ovarian cancer patients [6, 8, 9]. Primary peritoneal serous carcinoma (PPSC) is a rare tumor that lacks a prognostic prediction model. Our study aims to develop a nomogram to predict overall survival (OS) of PPSC patients. The nomogram compared the discrimination, calibration, and net benefits with the International Federation of Gynecology and Obstetrics (FIGO) staging system of PPSC patients
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