Abstract
This paper described a rugged and precise particle size determination method that has been developed and validated for the determination of particle size distribution of Ciprofloxacin Hydrochloride by a dry method using Malvern Mastersizer 2000.
 The Method of the particle size distribution of Ciprofloxacin Hydrochloride was precisely developed and validated successfully. By using parameters like Precision, Intermediate precision, and Robustness the method was validated. All the particle size data has been compiled and found to be satisfactory, Hence the method is suitably used for the analysis of the Particle size analyzer of Ciprofloxacin Hydrochloride active pharmaceutical ingredients.
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