Development and Validation of Knowledge, Attitude, and Practice Towards Antibiotics Questionnaire (KAPAQ) for General Community

Abstract

Understanding the knowledge, attitude, and practice (KAP) towards antibiotics with a valid and reliable questionnaire is essential to design an intervention to minimize misuse and overuse of antibiotics in the general community setting. This study aimed to develop and validate knowledge, attitude, and practice towards antibiotics questionnaire (KAPAQ). This study consists of the development and validation phase. The development questionnaire was based on a literature review, early individual interviews, and panel experts. The validation phase consisted of face, content, and construct validity. Content validity ratio (CVR) and content validity index (CVI) was used to analyze Content validity. Construct validity for attitude and practice was measured using exploratory factor analysis (EFA) and confirmatory factor analysis (CFA). Item analysis was employed for knowledge evaluation. Reliability was evaluated with internal consistency reliability and test-retest reliability. Validity and reliability were assessed using 407 respondents. The final KAPAQ consisted of three domains with 45 items. Items’ difficulty and discrimination index in the knowledge domain was acceptable, with the Cronbach’s α and test-retest reliability being 0.827 and 0.713, respectively. Four factor-solutions emerged for the attitude and practice domain with a cumulative contribution of 59.79% and 58.99%, respectively. The CFA result indicated acceptable fit indices for the proposed model. Every factor in both attitude and practice domain had an acceptable internal consistency and test-retest reliability range. The KAPAQ was psychometric valid and reliable to assess KAP among the general community towards antibiotics.